Welcome

SUMMARY

Biography

References

 

Texte Franšais

 

Asbestosis   of  prostate   and    bladder neck

 

Abstract

Asbestos fibers were found in prostate and bladder neck tissues of two  long time exposed  industry workers.  Etiology  and  anatomopathology are discussed.

In the first case,  asbestos fibers produced  progressive and  recurring fibrosis of the bladder outlet.  Urinary obstruction  required  a transurethral  resection  inducing retrograde ejaculation.  No cancerous evolution was noticed at the time of the paper, i.e. 21 years after the first contact with asbestos.

In the second case,  asbestos fibers were found in  resection  tissue from a prostate cancer   which developed  on the remaining  true prostate 10 years after open adenomectomy.  Various other industrial fibers were also identified.   The histological  aspect was very  unusual.  This might arouse the research assumption that  these fibers could have their own  influence on cancerous cell  typology.

For more informations and  a wide bibliography  see  the  paper  publication  :

( REFERENCES  page of this site )

 

Pathogenicity of asbestos  is not fully understood.

Molecular structure,  size of the fibers,  way of penetration,   severity and duration of exposure   inflect  the mode of  pathology.

          Inhaled fibers  cross  pleural membranes  by a  mechanism still to be cleared up. They  induce fibrous pleural plaques  which  may  develop into cancer,  not only the well known mesotheliomas  but  also malignancies of peritoneum, kidney,  testis, uterus,  digestive tract.

Necropsies find asbestos fibers in almost all organs,  including  spleen, thyro´d,  pancreas, heart, brain, prostate.

          Ingested fibres   are found only scarcely in abdominal organs.  Most are eliminated via  the urinary tract.  Asbestos ingestion happens in  industry conditions  but  fibers are also present in urine of populations who drink  soil polluted  water..

 

Histological diagnosis lays on  optical microscope  examination where granules made of  fibers wrapped in reticular cells  contain iron  and  are  identified  by  histochemical tests..

Electronic microscope  shows  asbestos fibers  free or  lying inside macrophagic cells.  Human derm fibroblasts  culture  brings  the proof  that asbestos  fibers induce  quick appearance of  multinucleate giant cells.

Mineralogical identification  and counting    is done by  electronic microscope after incineration.

Full description of all asbestos damages  is to be made up.

 

In some areas  of  french Normandy cutaneous asbestos carbuncles  are so familiar that they bear a vernacular common name

        

Mineralogical Analysis of prostate and bladder neck samples   Chrysotile fiber.

( First case,  next page  ).

 

Next Page    :  Relation of 2  cases